Motoneuron Meeting - Paris 2010
Scientific program
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Printable version
5 days calendar in PDF format
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Printable version
5 days program in PDF format

The introductory reviews and the special lecture lasted 30 minutes (including 5 min. discussion). All other talks were scheduled to last 15 minutes (including 3 min. discussion)

Friday 7/09

  • 8:30-8:50: Registration and Coffee
  • 8:55: Welcome
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Daniel Zytnicki
  • 9:00-10:30: Respiratory control of motoneuronal activity - Session given in honor of Peter Kirkwood; Chair: Karin Persson
    • Jack Feldman: Are respiratory motoneurons special? Introductory Review
    • Anna Hudson & Jane Butler: behaviour of human inspiratory motoneurones to voluntary and non-voluntary commands
    • Albert J Berger & Johannes van BrederodeGABAergic Control of Hypoglossal Motoneurons
    • Peter Kirkwood: Of course respiratory motoneurones are special  Special Lecture
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Karin Persson (left) and Peter Kirkwood (right)
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Jack Feldman
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Albert J. Berger
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Anna Hudson
  • 10:30-11:00: Coffee break
  • 11:00-12:00: Neuromodulation of intrinsic propertiesChair: Hilary Wakefield
    • Gareth Miles: Modulation of motoneurons by a spinal cholinergic system
    • Stan Nakanishi & Patrick Whelan: Dopaminergic modulation of locomotion.
    • David McCrea: Intrinsic spinal mechanisms increase motoneuron excitability during fictive scratch
    • Brent FedirchukEvidence of multiple and distinct modulatory mechanisms enhancing spinal motoneuron excitability during motor output
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Hilary Wakefield
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Brent Fedirchuk
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Stan Nakanishi (left) and David Mc.Crea (right)
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Gareth Miles
  • 12:00-12:30: General Discussion (Jean-François Perrier) 
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Jean-François Perrier
  • 12:30-13:30: Lunch
  • 13:30-15:00Poster Session 1 and Coffee
  • 15:00-15:30: Poster discussion (Randy Powers & Jane Butler)
  • 15:30-16:45 Development of the motor unit Chair: Lissa Herron
    • Klas Kullander: Novel markers for motor neurons enable genetic analysis of subpopulation development and function
    • Pascal LegendreGlycine release from radial cells modulates spontaneous activity during early spinal cord development
    • Claire Legay: Extracellular matrix and differentiation of the neuromuscular junction
    • Evelyne Bloch-Gallego: Development and maintenance of motoneurons: a key role of small GTPases and microtubule associated proteins
    • Eric Krejci: Functional and subsynaptic localization of acetylcholinesterase at the neuromuscular junction
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Lissa Herron
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Klas Kullander
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Pascal Legendre
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Claire Legay
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Evelyne Bloch-Gallego
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Eric Krejci
  • 16:45-17:15: Coffee break
  • 17:15-18:15: Historical sessionPaths of Discovery in Motoneuron Neurobiology  Chair: Jean-Gael Barbara
    • François Clarac and Jean Gael Barbara: Human motor pathologies and the emergence of motoneuronal concepts
    • Jacques Duchateau and Roger Enoka: Extracellular recording of human motor unit discharge: origin and insights into the integrated motor system
    • Douglas Stuart and Robert Brownstone: The beginning of intracellular recording in mammalian motoneurons: facts and speculations
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Jean-Gael Barbara
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François Clarac
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Jacques Duchateau
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Douglas Stuart

Saturday 7/10

  • 8:30-9:45: Firing properties in human subjects (1) Chair: Jennifer Stephenson
    • Simon GandeviaCentral fatigue and implications for motoneurone firing Introductory Review
    • Janet Taylor & Chris McNeilMotoneurone excitability with fatigue
    • Lydia Kudina & Regina E. Andreeva: Repetitive Doubling and Plateau Potentials in Human Motoneurones
    • Fiona Bailey: Task related variations in the discharge synchrony of human hypoglossal motor units 
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Jennifer Stephenson
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Simon Gandevia
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Chris McNeil
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Lydia Kudina
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Fiona Bailey
  • 9:45-10:15: Coffee break
  • 10:15-11:30 Synaptic inputs and motoneuronal excitability Chair: Alain Frigon
    • Rodolfo Delgado-Lezama: Control of monosynaptic reflex by GABAA receptors in the turtle spinal cord
    • Boris Lamotte d’Incamps: Recurrent inhibition: simple loop but complex synapses
    • Andrew FuglevandComparison of current-injected and synaptically-mediated activation of hypoglossal motor neurons
    • Aidas Alaburda: Activation of spinal motoneurons during fictive swim
    • Rune BergHow do we achieve precision in force? New mechanism for gain modulation in spinal motoneurons via Vm-fluctuations.
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Alain_Frignon (Rune Berg in background)
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Rodolfo Delgado-Lezama
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Boris Lamotte d’Incamps
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Andrew Fuglevand
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Aidas Alaburda
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Rune Berg
  • 11:30-12:00: General Discussion (C.J. Heckman) 
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CJ Heckman
    • 12:00-13:00: Lunch
    • 13:00-14:30Poster Session 2 and Coffee
    • 14:30-15:00: Poster discussion (Inge Zijdewind & Roger Enoka)
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    Inge Zijdewind
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    Roger Enoka
    • 15:00-16:00: Firing properties in human subjects (2) Chair: Matthew Holmes
      • Maria PiotrkiewiczLydia Kudina, Regina Andreeva, Dariusz Mlozniak: Recurrent inhibition in motoneurone pools of slow and fast human muscles
      • David F. Collins, Cameron S. Mang, Yoshino Okuma: Does the motor cortex contribute to “self-sustained” firing of human motoneurons?
      • Hiske van Duinen: control of the extrinsic muscles of the hand
      • Christiane Rossi-DurandInteraction between cognitive and motor tasks: Modulation of human motoneuron activity by a mental arithmetic task
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    Maria Piotrkiewicz
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    David F Collins
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    Hiske van Duinen
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    Christiane Rossi-Durand
    • 16:00-16:30: Coffee break
    • 16:30-17:30: Adaptations in motoneurons (Training, Chronic Pain, Aging) Chair: Caroline Iglesias
      • Phil Gardiner: Alpha-motoneuron adaptations to increased activity, from function to gene expression
      • Katrina Maluf: Motor responses to acute psychosocial stress in chronic neck pain
      • Andrew CresswellMotor unit discharge behaviour during brief and ballistic contractions in young and elderly adults
      • Roger Enoka & Michael A. Pascoe: Discharge characteristics of motor units at recruitment during sustained contractions differ for young and old humans
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    Caroline Iglesias
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    Phil Gardiner
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    Roger Enoka (foreground)
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    Katrina Maluf
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    Andrew Cresswell
    • 17:30-18:00: General Discussion (Hans Hultborn)
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    Hans Hultborn

    Sunday 7/11

    • 8:30-9:45: Plasticity in motoneuron properties after peripheral nerve injury Chair: Kevin Power
      • Tim CopeNew Lessons from Peripheral Nerve Injury: not just a problem in the periphery Introductory Review
      • Ken Rose: Growth of supernumerary axons from motoneuron dendrites following permanent axotomy
      • Francisco Alvarez: Reorganization of Ia afferent synapses on motoneurons after peripheral nerve injuries
      • Robert Fyffe: Plasticity in channel expression and localization in motoneurons after peripheral nerve injury
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    Kevin Power
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    Tim Cope (left) and_Ken Rose (right)
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    Francisco Alvarez
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    Robert Fyffe
    • 9:45-10:15: Coffee break
    • 10:15-11:30: New techniques to investigate motor unit properties in humans Chair: Katie Gant
      • Kemal Turker: Investigation of synaptic inputs to human motoneurons using frequency-based analysis; peristimulus frequencygram
      • Jens Bo Nielsen: Estimating recruitment gain of the motoneuronal pool in humans
      • Alexandra Lackmy & Veronique Marchand-Pauvert: Motoneurone pool properties and TMS in humans
      • Zev Rymer & Ping Zhou: Use of novel high density EMG grids to track motoneuron disease
      • Francesco Negro & Dario Farina: Sampling issues in correlation analysis between motor unit spike trains
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    Katie Gant
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    Kemal Turker
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    Jens Bo Nielsen
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    Alexandra Lackmy
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    Zev Rymer
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    Francesco Negro
    • 11:30-12:00: General Discussion (Christine Thomas)
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    Christine Thomas
    • 12:00: Apéritif with hors d’œuvre.
    • Afternoon free

    Monday 7/12

    • 8:30-10:00: Cellular basis of motoneuron excitability and firing properties  Chair: Estelle Drobac
      • Marc BinderDeconstructing persistent calcium currents in motoneurons: the where, the how and the why Introductory Review
      • Thomas Hamm: Comparison of discharge properties and persistent inward currents in normal motoneurons and motoneurons following incomplete spinal injury
      • Marin Manuel et al.: Fast subthreshold oscillations and sub-primary firing range in adult mouse motoneurons: implications for their motor units
      • Marc Davenne: The axon initial segments of mouse motoneurons
      • Florence Cotel & Jean-François Perrier: Serotonin induces central fatigue in motoneurons
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    Marc Binder
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    Thomas Hamm
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    Marin Manuel
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    Marc Davenne
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    Florence Cotel
    • 10:00-10:30: Coffee break
    • 10:30-11:45: Realistic models of motoneurons Chair: Matthieu Chardon 
      • CJ HeckmanModels of populations of motor units
      • Randy PowersSimulations of abnormal motor unit discharge behavior in spastic muscle.
      • Claude Meunier et al: Mechanisms of mixed mode oscillations in mouse spinal motoneurons
      • Gwendal Le MassonEnergy unbalance and motoneuron degeneration in ALS
      • Bob Lee: Relationship between pathology dynamics and treatment strategies: ALS and SCI case studies. 
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    CJ Heckman
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    Randy Powers
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    Claude Meunier
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    Gwendal Le Masson
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    Bob Lee
    • 11:45-12:15: General Discussion (Rob Brownstone)
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    Rob Brownstone
    • 12:15-13:15: Lunch
    • 13:15-14:30: Poster Session 3 and Coffee
    • 14:30-15:00: Poster discussion (Christiane Rossi-Durand & Kelvin Jones)
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    Christiane Rossi-Durand
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    Kelvin Jones
    • 15:00-16:30: Motoneuron properties after spinal cord injury and cerebral stroke Chair: Anna Hudson
      • Jonathan Carp: Spinal transection in adult rats alters the intrinsic properties of urethral sphincter motoneurons recorded in vitro 
      • Christine Thomas, Samuel Beckerman, James Atkison, Jeffrey Winslow, Marine Dididze: Alterations in motoneuron properties with chronic human spinal cord injury.
      • Inge Zijdewind, Katie Merritt, Rob Bakels Christine Thomas: Do additional inputs change voluntary motor unit firing rates after spinal cord injury?
      • Rose Katz: Pathophysiology of spinal circuitry following cerebral lesions in humans
      • Jayne GarlandMotoneurone afterhyperpolarization time course in humans following stroke
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    Anna Hudson
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    Jonathan Carp
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    Christine Thomas
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    Inge Zijdewind
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    Rose Katz
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    Jayne Garland
    • 16:30-17:00: General Discussion (Paul Hodges)
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    Paul Hodges
    • 17:30: Bus to the meeting Dinner

    Tuesday 7/13

    • 8:30-10:15: Motoneuron diseases (from genetics to pathophysiology) (1) Chair: Amélie Freal
      • Bernhard Keller: Novel aspects of motoneuron diseases: from genetics to pathophysiology Introductory Review
      • Judith Melki: Genomics and transcriptomics in motor neuron disease
      • Suzie Lefebvre: Cellular functions of the spinal muscular atrophy gene product SMN in RNA metabolism
      • Mihai Moldovan: Abnormal motor axon function in the transgenic SOD1 (G127X) mouse model of amyotrophic lateral sclerosis
      • Séverine Deforges & Frédéric Charbonnier: Exercise-specific induced neuroprotection in ALS mice.
      • Kelvin Jones & Tessa Gordon: Motor unit type and disease progression in the SOD1 mouse model of ALS and strategies for neuroprotection.
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    Bernhard Keller
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    Judith Melki
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    Suzie Lefebvre
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    Mihai Moldovan
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    Séverine Deforges
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    Kelvin Jones
    • 10:15-10:45: Coffee break
    • 10:45 - 12:15: Motoneuron diseases (from genetics to pathophysiology) (2) Chair: Walter Babiec
      • George MentisAltered intrinsic properties and synaptic dysfunction of motor neurons in a mouse model of spinal muscular atrophy 
      • Cristina Zona: Branched-chain amino acids induce hyperexcitability in motorneurons. Their possible involvement in Amyotrophic Lateral Sclerosis ethiopathology
      • Jacques DurandPostnatal alterations in lumbar motoneurons from SOD1 transgenic mice, an animal model of amyotrophic lateral sclerosis. 
      • Claire Meehan & Hans Hultborn: In vivo recordings from motoneurones in the SOD mouse
      • Daniel Zytnicki: Searching for altered properties of motoneurons in adult SOD1 mice
      • Rob Brownstone: In search of lost motoneurons or "A la recherche du motoneurone perdu"
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    George Mentis
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    Cristina Zona
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    Jacques Durand
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    Claire Meehan
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    Daniel Zytnicki
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    Rob Brownstone
    • 12:15-12:45: General Discussion (Zev Rymer)
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    Zev Rymer
    • 12:45-13:45: Lunch
    • 13:45 - 14:45: Final Discussion (Janet Taylor & Jørn Hounsgaard)
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    Janet Taylor
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    Jørn Hounsgaard
    • 14:45 - 15:00Best posters awards; Announcement of the next meeting

    Last update on Tuesday 26 October 2010

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